Effect of continuous positive airway pressure on blood pressure and related inflammatory factors in patients with obstructive sleep apnea hypopnea syndrome related hypertension
Objective To investigate the effect of continuous positive airway pressure(CPAP)on blood pressure and related inflammatory factors in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)related hypertension.Methods A total of 100 patients with OSAHS related hypertension admitted to Affiliated Hospital of Heze Medical College from Jan-uary 2020 to May 2022 were selected as the research objects.According to the random number table method,they were di-vided into CPAP group(50 cases)and control group(50 cases).The control group was given conventional antihypertensive drug treatment,and the CPAP group was given CPAP on the basis of the treatment method of the control group.The levels of ambulatory blood pressure,sleep monitoring indexes and related inflammatory factors before and after treatment were com-pared between the two groups.Results After treatment,the 24-hour average systolic blood pressure(24 hSBP),24-hour av-erage diastolic blood pressure(24 hDBP),night average systolic blood pressure(nSBP),night average diastolic blood pres-sure(nDBP),daytime average systolic blood pressure(dSBP),and daytime average diastolic blood pressure(dDBP)in the CPAP group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the apnea hypopnea index(AHI)and oxygen desaturation index(ODI)of the CPAP group were lower than those of the control group,and the lowest blood oxygen saturation(LSaO2)and mean oxygen saturation(MSaO2)were higher than those of the control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the CPAP group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion CPAP can significantly reduce the blood pressure and related inflammatory factors in patients with OSAHS related hyper-tension,and improve their respiratory function.
维普
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