Distribution characteristics and clinical manifestations of Epstein-Barr virus in 1 619 children
Objective To investigate the distribution,trend and clinical symptoms of Epstein-Barr virus(EBV)infection a-mong children to provide evidence for early diagnosis of EBV infection.Methods Real-time fluorescence quantitative PCR was used to detect EB-DNA in 4 667 children in Department of Pediatrics of the Third Hospital of Mianyang from January 2019 to December 2021.Statistical analysis was carried out on the test results.Study on the correlation between EBV infec-tion and gender,age,and season in pediatric patients.Results Among 4 667 children,1619 were found to be positive for EB-DNA,with a positive rate of 34.70％.There was no statistical difference in the positive rate of EB-DNA between male and female children.The positive rate of EB-DNA in winter was higher than that of spring,and the difference was statisti-cally significant(P＜0.008).The positive rate of EB-DNA was the highest in the school-age group and the lowest in the in-fant group.The typical clinical manifestations of infectious mononucleosis(such as fever,angina and lymphadenopathy)were more common after EBV infection.Conclusion School-age children are susceptible to EBV infection,and the clinical symptoms such as fever,angina and lymphadenopathy are more common.Winter is the season of high incidence of EBV infection.The highest EBV infection rate was found in school-age children.
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