Application effect of different doses of Esketamine combined with Sufen-tanil on patient-controlled intravenous analgesia after cesarean section
Objective To explore the application effect of different doses of Esketamine combined with Sufentanil on pa-tient-controlled intravenous analgesia(PCIA)after cesarean section.Methods A total of 148 puerperae who underwent ce-sarean section in Shangrao People's Hospital from March 2022 to March 2023 were selected as the study objects,and they were divided into high-dose group(74 cases)and low-dose group(74 cases)according to random number table method.The low-dose group was diluted with normal saline to 150 ml of 1.5 μg/kg Sufentanil d+4 mg of Tropisetron+0.1 mg/kg Eske-tamine,and the high-dose group was diluted with normal saline to 150 ml of 1.5 μg/kg Sufentanil+4 mg of Tropisetron+0.2 mg/kg Esketamine.The hemodynamics(heart rate[HR],mean arterial pressure[MAP],blood oxygen saturation[SpO2])and pain status(short-form McGill pain questionnaire[SF-MPQ])were compared between the two groups at the end of surgery and at 1 and 2 day after surgery,and the differences in anesthesia-related adverse reactions in the two groups were analyzed.Results The HR and MAP in the two groups at 1 and 2 day after surgery were higher than those at the end of surgery,and the HR and MAP in high-dose group were lower than those in low-dose group,and the differences were statistically significant(P＜0.05).The SpO2 in high-dose group at 1 day after surgery was lower than that at the end of surgery,and the difference was statistically significant(P＜0.05).The SpO2 in low-dose group at 1 and 2 days after surgery was lower than that at the end of surgery(P＜0.05).There was no statistical difference in SpO2 in high-dose group at 2 days after surgery compared with that at the end of surgery(P＞0.05).The SpO2 in high-dose group was higher than that in low-dose group at 1 and 2 day after surgery,and the difference was statistically significant(P＜0.05).The SF-MPQ scores in both groups were lower at 1 and 2 days after surgery than those at the end of surgery,and the scores in high-dose group were lower than those in low-dose group at 1 and 2 day after surgery,and the differences were statistically significant(P＜0.05).The total incidence rate of adverse reactions in high-dose group was lower than that in low-dose group,and the difference was statistically significant(P＜0.05).Conclu-sion The effect of 0.2 mg/kg Esketamine combined with Sufentanil in PCIA after cesarean section is better than that of 0.1 mg/kg Esketamine,and the former one can better maintain the hemodynamic indicator stability and has exact analgesic effect,and the safety is not affected by the dose of Esketamine.
万方数据
维普
