Objective To investigate the clinical efficacy of Norepinephrine combined with Pituitrin in the treatment of sep-tic shock.Methods A total of 62 patients with septic shock admitted to ICU of Yangzhou Hospital of Traditional Chinese Medicine from September 2017 to May 2023 were selected as the study objects,and they were divided into observation group and control group according to random number table method,with 31 cases in each group.The control group was treated with Norepinephrine on the basis of routine fluid rehydration and anti-infection treatment to maintain blood pressure,while the observation group was treated with Pituitrin on the basis of the control group.The changes of blood lactic acid and urine volume at 6,24,48 and 72 h after treatment of the two groups were counted,and the success rate of fluid resuscitation within 6 h,28-day mortality and adverse reactions of the two groups were counted.Results After treatment,the decrease level of blood lactic acid in observation group at 6,24,48 and 72 h were higher than those in control group,and the differ-ences were statistically significant(P＜0.05).After treatment,urine volume at 6,24,48 and 72 h in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The success rate of fluid resuscitation within 6 h in the observation group was higher than that in the control group,and the 28-day fatality rate in the observation group was lower than that in the control group,the differences were statistically significant(P＜0.05).There was no statistical significance in the total incidence of adverse reactions between the two groups(P＞0.05).Conclu-sion The combination of Norepinephrine and Pituitrin in the treatment of septic shock can improve patients'blood lactate levels and urine output,increase the success rate of fluid resuscitation at 6 hours,and reduce the 28-day mortality rate.This treatment approach may offer clinical benefits for patients with septic shock,the security of this method is guaranteed.
维普
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