中国当代医药2024,Vol.31Issue(22) :68-71.

含奥沙利铂化疗方案联合艾迪注射液对晚期结直肠癌患者免疫功能及生活质量的影响

Effect of Oxaliplatin-containing chemotherapy combined with Aidi Injec-tion on immune function and quality of life in patients with advanced col-orectal cancer

付先锋 晏燕 黄筠
中国当代医药2024,Vol.31Issue(22) :68-71.

含奥沙利铂化疗方案联合艾迪注射液对晚期结直肠癌患者免疫功能及生活质量的影响

Effect of Oxaliplatin-containing chemotherapy combined with Aidi Injec-tion on immune function and quality of life in patients with advanced col-orectal cancer

付先锋 1晏燕 2黄筠3
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作者信息

  • 1. 江西中医药大学附属医院肿瘤科,江西南昌 330006
  • 2. 江西中医药大学附属医院手术室,江西南昌 330006
  • 3. 江西中医药大学附属医院综合门诊,江西南昌 330006
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摘要

目的 探讨含奥沙利铂化疗方案联合艾迪注射液对晚期结直肠癌(CRC)患者免疫功能及生活质量的影响.方法 选取2021年3月至2023年3月江西中医药大学附属医院收治的93例CRC患者,按照随机数字表法分为对照组(47例)与试验组(46例).对照组给予含奥沙利铂化疗方案治疗,在其基础上,试验组给予艾迪注射液治疗,比较两组临床疗效、免疫功能、肿瘤标志物水平与生活质量.结果 试验组总有效率、CD4+与CD3+、生活质量总改善率均高于对照组,CD8+、糖类抗原125(CA125)、癌胚抗原(CEA)与糖类抗原19-9(CA19-9)均低于对照组,差异有统计学意义(P<0.05).结论 含奥沙利铂化疗方案、艾迪注射液联合治疗晚期CRC疗效确切,可降低肿瘤标志物水平,增强免疫功能,提高生活质量.

Abstract

Objective To explore the effect of Oxaliplatin-containing chemotherapy regimen combined with Aidi Injection on immune function and quality of life of patients with advanced colorectal cancer(CRC).Methods A total of ninety-three patients with CRC admitted to the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from March 2021 to March 2023 were selected as the study objects and they divided into the control group(47 cases)and the experimental group(46 cases)according to random number table method.The control group was treated with Oxaliplatin-containing chemotherapy regimen,and on its basis,the experimental group was treated with Aidi Injection,and the clinical efficacy,immune function,tumor marker levels and quality of life of the two groups were compared.Results The total effective rate,CD4+and CD3+,and total improvement rate of quality of life of the experimental group were higher than that of the control group,and CD8+,carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9)were lower than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The combined treatment of advanced CRC with Oxaliplatin-containing chemotherapy regimen and Aidi Injection is effica-cious and can reduce the level of tumor markers,enhance the immune function and improve the quality of life.

关键词

结直肠癌/晚期/含奥沙利铂化疗方案/艾迪注射液/免疫功能

Key words

Colorectal cancer/Advanced stage/Oxaliplatin-containing chemotherapy regimen/Aidi injection/Immune function

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基金项目

江西省卫生健康委科技计划项目(202310675)

出版年

2024
中国当代医药
中国保健协会 当代创新(北京)医药科学研究院

中国当代医药

影响因子:1.215
ISSN:1674-4721
参考文献量20
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