Objective In order to enhance the clinical thinking ability of clinical pharmacy interns during the clinical in-ternship stage and explore the application effect of the SOAP thinking mode in the clinical teaching process.Methods Thir-ty-two clinical pharmacy students who practiced in the Affiliated Hospital of Weifang Medical University from June 2021 to June 2023 were selected as the study objects,and they were divided into experimental group(16 students)and control group(16 students)according to the block group randomization method.The control group adopted the traditional teaching method,and the experimental group adopted the SOAP thinking mode teaching method.The results of basic knowledge assessment,medical history writing score,practice defense score and teaching effect evaluation were compared between the two groups.Results There was no significant difference between the two groups in basic knowledge assessment(P>0.05).The score of drug history writing in experimental group was higher than that in control group,and the difference was statistically significant(P<0.05).The test result of experimental group was better than that of control group,and the difference was sta-tistically significant(P<0.05).The teaching satisfaction,learning interest and clinical thinking ability,of experimental group were better than those in control group and the differences were statistically significant(P<0.05).Conclusion The use of SOAP clinical thinking mode to teach clinical pharmacy students can better improve the clinical thinking ability of intern students,establish the thinking mode of clinical pharmacists earlier,and further improve the role of clinical pharmacists in clinical practice and reflect the value of clinical pharmacists.