首页|血必净注射液对脓毒症者炎症因子水平及序贯器官功能衰竭评分的影响

血必净注射液对脓毒症者炎症因子水平及序贯器官功能衰竭评分的影响

Effect of Xuebijing Injection on the level of inflammatory factors and se-quential organ failure assessment score in patients with sepsis

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目的 探讨脓毒症者应用血必净注射液治疗对炎症因子水平、序贯器官功能衰竭(SOFA)评分的影响.方法 选取2021年6月至2023年6月江西省新余北湖医院接诊的91例脓毒症患者作为研究对象,按照随机数字法分成对照组(n=46)和研究组(n=45).对照组按照脓毒症指南予常规西医治疗,研究组于此基础上予血必净注射液治疗.比较两组炎症因子水平、凝血功能、预后情况[SOFA、急性生理学及慢性健康状况评分Ⅱ(APACHEⅡ)].结果 治疗后,研究组白介素-6(IL-6)、降钙素原(PCT)、凝血酶原时间(PT)、肿瘤坏死因子-α(TNF-α)、活化部分凝血酶时间(APTT)、D-二聚体、凝血酶时间(TT)和APACHE Ⅱ、SOFA评分均低于对照组,差异有统计学意义(P<0.05).结论 在脓毒症治疗中应用血必净注射液可改善凝血功能,抑制炎症因子表达,改善患者预后.
Objective To investigate the effects of Xuebijing Injection on levels of inflammatory factors and sequential organ failure assessment(SOFA)score in patients with sepsis.Methods A total of 91 patients with sepsis from Xinyu Beihu Hos-pital of Jiangxi Province from June 2021 to June 2023 were selected as the research objects and divided into control group(n=46)and study group(n=45)according to random number method.The control group was treated with conventional West-ern medicine in accordance with sepsis guidelines,and the study group was treated with Xuebijing Injection on this basis.The levels of inflammatory factors,coagulation function and prognosis(SOFA,acute physiology and chronic health status score Ⅱ[APACHE Ⅱ])of the two groups were compared.Results After treatment,the interleukin-6(IL-6),procalcitonin(PCT),prothrombin time(PT),tumor necrosis factor-α(TNF-α),activated partial thrombin time(APTT),D-dimer,throm-bin time(TT),score of APACHE Ⅱ and score of SOFA in the study group were lower than those in the control group,the dif-ferences were statistically significant(P<0.05).Conclusion The application of Xuebijing Injection in the treatment of sep-sis can improve the coagulation function,inhibit the expression of inflammatory factors and improve the prognosis of patients.

SepsisHemopexin injectionInflammatory factor levelPrognosis

胡海强、江怡、谢勇

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江西省新余北湖医院重症医学科,江西新余 338000

江西省新余市中医院重症医学科,江西新余 338000

江西省新余北湖医院心血管内科,江西新余 338000

脓毒症 血必净注射液 炎症因子水平 预后情况

江西省中医药管理局科技计划项目

2022B661

2024

中国当代医药
中国保健协会 当代创新(北京)医药科学研究院

中国当代医药

影响因子:1.215
ISSN:1674-4721
年,卷(期):2024.31(24)
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