Objective To investigate the diagnostic value of serum kidney injury molecule 1(KIM-1),cystatin C(Cys-C)and urinary microalbumin(UmAlb)in early diabetic nephropathy(DN).Methods A total of 114 diabetic patients admitted to Jiujiang Hospital of Traditional Chinese Medicine from May 2019 to April 2022 were selected as the study objects to evalu-ate the occurrence of early DN and divided into early DN occurrence group and non-occurrence group.The levels of serum KIM-1,Cys-C and UmAlb were detected and compared between the two groups,and the value of combined detection of serum KIM-1,Cys-C and UmAlb in the diagnosis of early DN were analyzed.Results Early DN occurred in 37 of 114 dia-betic patients(32.46％).The levels of KIM-1,Cys-C and UmAlb in the early DN group were higher than those of the non-DN group,and the differences were statistically significant(P＜0.05).The ROC curve showed that the AUC value of serum KIM-1,Cys-C and UmAlb in the diagnosis of early DN were more than 0.080,which had certain diagnostic value,and the combined detection had the highest diagnostic value.Conclusion The combined detection of serum KIM-1,Cys-C and UmAlb in the diagnosis of early DN has high application value,and has important guiding significance for clinical diag-nosis and treatment.
关键词
糖尿病肾病/肾损伤分子1/胱抑素-C/尿微量清蛋白/诊断价值
Key words
Diabetes nephropathy/Kidney injury molecule 1/Cystatin-C/Urine microalbumin/Diagnostic value
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