摘要
目的 探讨不同湿化方式对慢性阻塞性肺疾病无创通气患者的影响.方法 选取2022年7月至2023年5月广西医科大学第一附属医院收治并被诊断为慢性阻塞性肺疾病的120例接受无创通气的患者作为研究对象,按照随机数字表法分为三组,分别接受三种不同湿化方式,即A组(40例):使用MR850湿化罐加热湿化;B组(40例):使用MR850湿化罐加热湿化+间断氧气驱动雾化;C组(40例):使用超声雾化器加温湿化.连续3～7 d进行临床和试验观察,包括吸入气体温度、相对湿度和绝对湿度、痰液黏稠度和舒适度评分.结果 无创通气治疗后,三组相对湿度、绝对湿度、气体温度和痰液黏稠度均高于本组治疗前,差异有统计学意义(P＜0.05);B组和C组的相对湿度、绝对湿度、气体温度、痰液黏稠度和舒适度水平评分高于A组,差异有统计学意义(P＜0.05);C组的相对湿度、绝对湿度、气体温度和痰液黏稠度水平评分高于B组,差异有统计学意义(P＜0.05);C组舒适度水平评分高于B组,差异有统计学意义(P＜0.05).结论 使用超声雾化器加温湿化可以更好地改善患者痰液黏稠,促进排痰,提高慢性阻塞性肺疾病患者使用无创通气治疗效果.
Abstract
Objective To explore the effect of different humidification methods on non-invasive ventilation in patients with chronic obstructive pulmonary disease.Methods A total of 120 patients diagnosed with chronic obstructive pulmonary dis-ease who received non-invasive ventilation and were admitted to the First Affiliated Hospital of Guangxi Medical University from July 2022 to May 2023 were selected as the study objects,and they were divided into three groups according to random number table method,each receiving a different humidification method:Group A(40 cases):heated humidification using an 850 ml humidifier,Group B(40 cases):heated humidification using an 850 ml humidifier combined with intermittent oxygen-driven nebulization,and Group C(40 cases):warm humidification using an ultrasonic nebulizer.Clinical and experimental observations were conducted continuously for 3 to 7 days,including measurements of inhaled gas temperature,relative humidity,absolute humidity,sputum viscosity,and comfort scores.Results After non-invasive ventilation treatment,the scores of relative humidity,absolute humidity,gas temperature,and sputum viscosity levels in the three groups were higher than before treatment,and the differences were statistically significant(P＜0.05).The relative humidity,absolute hu-midity,gas temperature,sputum viscosity,and comfort level scores of Group B and Group C were higher than those of Group A,and the differences were statistically significant(P＜0.05).The scores of relative humidity,absolute humidity,gas tem-perature,and sputum viscosity level in Group C were higher than those in Group B,and the differences were statistically significant(P＜0.05).The comfort level score of Group C was higher than that of Group B,and the difference was statistically significant(P＜0.05).Conclusion The use of ultrasonic atomizers for warming and humidification can better improve the viscosity of sputum in patients,promote sputum excretion,and enhance the efficacy of non-invasive ventilation treatment in patients with chronic obstructive pulmonary disease.
基金项目
广西壮族自治区卫生健康委员会自筹经费科研课题(Z-A20220504)
维普
万方数据