Effect of Shangke Xiaozhong Zhitong Ointment combined with Celecoxib Capsules on the treatment of acute gouty arthritis and its inflammatory indicators
Objective To investigate the clinical effect of Shangke Xiaozhong Zhitong Ointment combined with Celecoxib Capsules in the treatment of acute gouty arthritis(GA)and its influence on related inflammatory indexes.Methods A total of 120 patients with cold-dampness impediment acute GA admitted to the Department of Emergency of Ganzhou Hospital of TCM from January to December 2023 were selected as the research objects,and they were divided into Chinese medicine group,western medicine group and combination group according to random number table method,with 40 cases in each group.After screening according to inclusion,exclusion and exclusion criteria,113 patients actually participated in the study,including 38 patients in the Chinese medicine group,36 patients in the western medicine group,and 39 patients in the combination group.The Chinese medicine group was treated with external application of Shangke Xiaozhong Zhitong Ointment,the western medicine group was treated with Celecoxib Capsules,and the combination group was treated with Shangke Xiaozhong Zhitong Ointment combined with Celecoxib Capsules for 1 week.Visual analogue scale(VAS)score,erythrocyte sedimentation rate(ESR),blood uric acid(BUA),inflammatory factors(interleukin-6[IL-6],tumor necrosis factor-α[TNF-α],C-reactive protein[CRP])levels,traditional Chinese medicine syndrome score and therapeutic effect were compared among the three groups.Results After treatment,VAS score,ESR,BUA,IL-6,TNF-α,CRP and traditional Chinese medicine syndrome score of the three groups were lower than those before treatment,and all indexes of the combination group were lower than those of the Chinese medicine group and the western medicine group,with statistical significances(P＜0.05).The total effective rate of combination group was higher than those of Chinese medicine group and western medicine group,and the differences were statistically significant(P＜0.05).Conclusion The combination of Celecoxib Capsules and Shangke Xiaozhong Zhitong Ointment in the treatment of acute GA is effective,which can effectively improve the levels of ESR and BUA,reduce the levels of inflammatory factors,relieve the pain and traditional Chinese medicine symptoms of patients.
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