Clinical effect of Roxadustat in the treatment of renal anemia in mainte-nance hemodialysis patients
Objective To investigate the efficacy of Roxadustat in the treatment of renal anemia in maintenance hemodialy-sis patients.Methods A total of 81 patients who hemoglobin＜110 g/L and received regular hemodialysis for more than 3 months in Yichun People's Hospital from January 2021 to June 2022 were selected as the study objects.They were divided into observation group(n=40)and control group(n=41)using the random number table method.The control group was treat-ed with recombinant human erythropoietin,and the observation group was treated with Roxadustat.Relevant laboratory indi-cators were improved on an empty stomach before medication,and blood was taken again at 12 weeks after medication.The efficacy,iron metabolism index,lipid metabolism index,inflammatory factors and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).After treatment,the serum ferritin level in observation group was lower than that in control group,and the transferrin saturation and transferrin level were higher than that in control group,the differences were statistically significant(P＜0.05).After treatment,the levels of cholesterol,triglyceride and low-density lipoprotein in observation group were lower than those in control group,and the differences were statistically significant(P＜0.05).After treatment,the levels of C-reactive protein and interleukin-6 in observation group were lower than those in con-trol group,and the differences were statistically significant(P＜0.05).There was no significant difference in the total inci-dence of adverse reactions between the two groups(P＞0.05).Conclusion Roxadustat,as a treatment option for maintaining renal anemia in hemodialysis patients,has significant efficacy and clinical application prospect with high safety.
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