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脓毒症相关急性肾损伤新型生物标志物的研究进展

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脓毒症是一种因机体对感染反应后导致多器官功能障碍的全身炎症性反应综合征,其中肾脏是最受影响的器官之一,在全球范围内脓毒症合并急性肾损伤的发病率一直居高不下,且因其预后不佳,是急诊医学及重症医学的重难点。因此,在临床上早期诊断及早期干预治疗脓毒症相关急性肾损伤(SA-AKI)至关重要,目前依赖尿量及血清肌酐学的急性肾损伤诊断标准存在一定的限制,进而延迟早期的诊断及有效的治疗。本文通过总结SA-AKI生物标志物研究的最新进展,旨在弥补对其早期诊断方面的空白。
Research progress in novel biomarkers of sepsis-associated acute kidney injury
Sepsis is a systemic inflammatory response syndrome that causes multiple organ dysfunction due to the body's response to infection,kidney is one of the most affected organs.The incidence of sepsis combined with acute kidney injury has been high worldwide,and due to its poor prognosis,it is a major difficulty in emergency medicine and intensive care medicine.Therefore,early diagnosis and early intervention in the clinical treatment of sepsis-associated acute kidney injury(SA-AKI)are crucial.The current diagnostic criteria for acute kidney injury that rely on urine volume and serum creatinine have certain limitations,thus delaying early diagnosis and effective treatment.In this paper,we summarize the latest progress of SA-AKI biomarker research,aiming to fill the gap in the early diagnosis of SA-AKI.

SepsisAcute kidney injurySepsis-associated acute kidney injuryBiomarker

尼格热·阿布都艾尼、谢姆孜牙·买买提热夏提

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新疆医科大学附属肿瘤医院重症医学科,新疆乌鲁木齐 830011

脓毒症 急性肾损伤 脓毒症相关急性肾损伤 生物标志物

2024

中国当代医药
中国保健协会 当代创新(北京)医药科学研究院

中国当代医药

影响因子:1.215
ISSN:1674-4721
年,卷(期):2024.31(25)