Objective To systematically evaluate the effect of zinc supplementation during pregnancy on neonatal birth weight,and to provide evidence for reasonable zinc supplementation during pregnancy.Methods Databases including CN-KI,CBM,WanFang Data,Web of Science,PubMed,EMbase,Cochrane Library,Ebsco were searched to collect randomized controlled trials(RCT)on the effect of zinc supplementation during pregnancy on neonatal birth weight were to provide evi-dence basis for rational zinc supplementation during pregnancy from inception to May 2022.Two researchers independently conducted back-to-back literature screening,data extraction and risk assessment of literature quality bias.Meta analysis was performed by RevMan 5.3 software.Results A total of 10 RCTs were included in the study,including 4 267 subjects.The results of meta analysis results showed that:compared with control group,zinc supplementation during pregnancy had no significant effect on neonatal birth weight(MD=6.87,95％CI:-18.47-32.21,P=0.60).The results of subgroup analysis showed that there was no statistically significant difference between the zinc supplemention during pregnancy in the group with low zinc basal level(MD=-7.61,95％CI:-69.90-54.68,P=0.81),and in the group with normal zinc basal level(MD=16.83,95％CI:-28.17-61.84,P=0.46)(P＞0.05).And there was no statistically significant difference between the zinc supple-mentation alone during pregnancy(MD=-3.09,95％CI:-55.19-49.0,P=0.91)and combination of multiple micronutrients containing zinc(MD=20.95,95％CI:-40.95-82.36,P=0.50)(P＞0.05).Conclusion Current evidence shows that Zinc sup-plementation during pregnancy had no significant effect on neonatal birth weight.Due to the limited quality and quantity of the included literature,this conclusion needs to be validated by more high-quality studies.
维普
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