Objective To investigate the clinical effect of goal-directed fluid therapy(GDFT)in patients undergoing la-paroscopic liver surgery.Methods A total of 62 patients with laparoscopic liver surgery admitted to Yantai Yantaishan Hos-pital from March 2020 to August 2023 were selected as the research objects.According to the random number table method,they were divided into the reference group(31 cases)and the study group(31 cases).The reference group was treated with conventional methods,and the study group was treated with GDFT.The mini-mental state examination(MMSE)score,hemodynamic index levels,blood urea nitrogen(BUN)and lactic acid(Lac)levels were compared between the two groups.Results There was no significant difference in MMSE score between the two groups 1 day before operation(P＞0.05).At 1 and 3 days after operation,MMSE scores in the study group were higher than those in the reference group,and the differences were statistically significant(P＜0.05).The cardiac index(CI)at the time of liver resection(T2)and the end of surgery(T3)in the study group were higher than those in the control group;The central venous pressure(CVP)level at T2 was higher than that in the reference group,and that at T3 was lower than that in the reference group,with statistical significance(P＜0.05).There were no significant differences in BUN level between the two groups at the time of entry(T0),T3 and 24 h after surgery(P＞0.05).At T0,there was no significant difference in Lac level between the two groups(P＞0.05).At T3 and 24 h after operation,Lac levels in study group were lower than those in reference group,and the differences were statistically significant(P＜0.05).Conclusion In clinical practice,reasonable GDFT treatment for patients undergoing laparoscopic liver surgery has obvious effects on the stability of blood perfusion of patients'important organs and the maintenance of the hemo-dynamic level of patients,which can protect the brain tissue of patients and promote the improvement of postoperative cognitive function of patients.
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