Association between helper T cell 1/helper T cell 2 marker cytokines and short-term and long-term efficacy of chemotherapy for advanced lung adenocarcinoma
Association between helper T cell 1/helper T cell 2 marker cytokines and short-term and long-term efficacy of chemotherapy for advanced lung adenocarcinoma
Objective To analyze the association between helper T cell(TH)1/TH2 marker cytokines and short-term and long-term efficacy of chemotherapy for advanced lung adenocarcinoma.Methods A total of 82 patients with advanced lung adenocarcinoma admitted in Xuzhou Hospital of TCM from January 2021 to December 2023 were selected as the study sub-jects.All patients were treated with Pemetrexed+Cisplatin or Carboplatin and were treated for 3 consecutive cycles by tak-ing 21 days as a cycle.The changes of serum interferon-γ(IFN-γ),interleukin(IL)-2,IL-4 and IL-10 and occurrence of adverse reactions were compared among patients with different short-term clinical efficacies before chemotherapy and after 3 cycles of chemotherapy.The differences in serum IFN-γ,IL-2,IL-4 and IL-10 after 3 cycles of chemotherapy were recorded in survivors and dead person at 2 years after chemotherapy.Results All 82 patients with advanced lung adenocar-cinoma completed 3 cycles of chemotherapy,including 1 case of complete response(CR),34 cases of partial response(PR),28 cases of stable disease(SD)and 19 cases of progress disease(PD).Serum IFN-γ and IL-2 in patients with advanced lung adenocarcinoma after 3 cycles of chemotherapy were enhanced compared with those before chemotherapy,while serum IL-4 and IL-10 were lower than before chemotherapy,with statistical significances(P＜0.05).After chemotherapy,serum IFN-γ and IL-2 in CR+PR patients were higher than those in SD+PD patients,while serum IL-4 and IL-10 were lower than those in SD+PD patients,with statistical significances(P＜0.05).There was no significant difference in the total inci-dence rates of adverse reactions during chemotherapy be-tween CR+PR patients and SD+PD patients(P＞0.05).A-mong the 42 patients with advanced lung adenocarcinoma who obtained follow-up endpoints,8 cases(19.05％)died and 34 cases(80.95％)survived.Serum IFN-γ and IL-2 of dead person at 2 years after chemotherapy were lower than those of the survivors after 3 cycles of chemotherapy,while serum IL-4 and IL-10 were higher than those of the survivors,with statistical significances(P＜0.05).Conclusion TH1/TH2 balance is not only related to the short-term efficacy of chemotherapy,but also related to the long-term prognosis survival of patients with advanced lung adenocarcinoma.
关键词
肺腺癌/晚期/化疗/辅助性T细胞1/辅助性T细胞2/细胞因子/疗效/预后
Key words
Lung adenocarcinoma/Advanced/Chemotherapy/Helper T cell 1/helper T cell 2/Cytokines/Efficacy/Prog-nosis
维普
万方数据