Clinical and etiological characteristics of patients with liver abscess of Klebsiella pneumoniae
Objective To analyze the clinical features,laboratory examination indexes and drug susceptibility characteris-tics of Klebsiella pneumoniae patients with liver abscess,and provide reference for early clinical diagnosis and treatment.Methods The clinical data of 145 patients with liver abscess admitted to Traditional Chinese Medicine Hospital of Wuyi from January 2019 to December 2023 were retrospectively analyzed,and they were divided into Klebsiella pneumoniae liver abscess group(KPLA group)and non-Klebsiella pneumoniae liver abscess group(NKPLA group)according to the aetiologi-cal detection results.The clinical characteristics,laboratory indexes,pathogen resistance and clinical outcomes of the two groups were compared.Results Among 145 patients with liver abscess,97 cases(66.90％)were positive for bacterial cul-ture,72 cases(74.23％)were Klebsiella pneumoniae,and the sensitivity of Klebsiella pneumoniae to most antibacterial drugs was more than 90％.The proportion of diabetes mellitus in KPLA group was higher than that in NKPLA group,and the proportion of liver and gallbladder diseases was lower than that in NKPLA group,the difference was statistically significant(P＜0.05).The clinical symptoms of KPLA patients were not typical,and the proportion of abdominal pain and chills in NKPLA group were higher than those that in KPLA group,the differences were statistically significant(P＜0.05).The levels of procalcitonin(PCT),C-reactive protein(CRP),alanine aminotransferase(ALT)and the proportion of patients with liver dysfunction in KPLA group were higher than those in NKPLA group,and the differences were statistically significant(P＜0.05).There were no statistically significant differences in length of stay,site of infection and clinical prognosis between the two groups(P＞0.05).Conclusions Klebsiella pneumoniae is the main pathogenic bacterium in patients with bacterial liver abscess complicated with diabetes mellitus.The pathogenic bacteria are sensitive to commonly used antibiotics,and the clinical symptoms of KPLA patients are not typical.Patients with abnormal PCT,CRP,ALT and abnormal liver function should be included in the early identification population.The above laboratory test results also have a certain guiding value for distinguishing the severity of infection.
万方数据
维普
