Objective To explore the medication rule of external treatment of chronic cheilitis with traditional Chinese medicine.Methods Literature on topical treatment of chronic cheilitis with traditional Chinese medicine was searched from CNKI,Wanfang,VIP,China Biomedicine,PubMed and other databases,and the search time was from the establishment of the database to January 2024.Further frequency analysis,cluster analysis,and association rule analysis were performed on the traditional Chinese medicine and its properties,flavors,and meridians in the retrieved prescriptions.Results Relevant articles were searched and organized according to the inclusion and exclusion criteria,with a total of 50 articles included,involving 86 traditional Chinese medicines.The top-10 high-frequency drugs were Sophora flavescens,Dictamnus dasycar-pus,Fructus cnidii,Radix lithospermi,Angelica sinensis,Kochia scoparia,Licorice,Phellodendron amurense,Coptis chi-nensis,and Borneol.The medication was dominated by heat-clearing drugs,deficiency-tonifying drugs,and drugs for re-lieving exterior syndrome,accounting for 54.49％,14.37％,and 9.58％,respectively;the medicinal property was mainly cold,accounting for 53.33％;and the medicinal flavors were mainly sweet,bitter,and pungent,which were 45.45％,27.27％,and 22.73％,respectively.Furthermore,medicines primarily acted on the stomach,gallbladder,lung,and large intestine meridi-ans,which were 16.67％,16.67％,14.29％and 14.29％,respectively.Three categories could be roughly established based on the cluster analysis.Association rule analysis revealed a major strong compatibility relationship between Dictamnus dasycarpus and Sophora flavescens.In addition,the dosage forms of traditional Chinese medicine for external treatment of chronic cheilitis were generally ointments and wa-ter-based agents,accounting for 42.31％and 36.54％,re-spectively.Conclusion The external treatment of chronic cheilitis with traditional Chinese medicine emphasizes mainly on damp heat in the spleen and stomach,and pathogenic fac-tors of wind and fire of Yangming stomach meridian,with special attention paid to clearing heat,promoting blood circulation and removing blood stasis,combined with therapeutic methods of relieving exterior syndrome and tonifying deficiency.The commonly used medicines are sweet and bitter in taste,as well as cold,warm and neutral in property.Findings in this study provide potential theoretical reference for the clinical application of traditional Chinese medicine for external treatment of chronic cheilitis.
Chronic cheilitisExternal treatment of traditional Chinese medicineData miningMedication rule
维普
万方数据
