首页|非酒精性脂肪性肝病发病的影响因素分析

非酒精性脂肪性肝病发病的影响因素分析

Analysis of influencing factors of nonalcoholic fatty liver disease

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目的 观察非酒精性脂肪性肝病(NAFLD)发病的相关影响因素.方法 选取2021年1月至2023年11月上饶市第二人民医院收治的82例NAFLD患者作为NAFLD组,另外选取50例同期体检健康者作为对照组,比较两组患者的腺苷脱氨酶(ADA)活性、甲状腺激素[游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)]及促甲状腺激素(TSH)水平,采用多因素logistic回归模型分析NAFLD发生的影响因素.结果 NAFLD组ADA活性、TSH水平高于对照组,且NAFLD组FT3与FT4水平低于对照组,差异有统计学意义(P<0.05).多因素logistic回归模型分析结果显示,ADA 活性(β=0.671,OR=1.956,95%CI:1.259~3.040)、FT3(β=-0.558,OR=1.747,95%CI:1.035~2.949)、FT4(β=-0.611,OR=0.543,95%CI:0.299~0.985)及 TSH(β=0.447,OR=1.564,95%CI:1.138~2.148)水平均为发生NAFLD的独立影响因素(P<0.05).结论 与健康人群比较,NAFLD患者ADA活性、TSH水平较高,FT3与FT4水平较低,且ADA活性、FT3、FT4及TSH水平均为发生NAFLD的独立影响因素,应采取针对性措施,降低NAFLD发生率,临床建议予以重点关注.
Objective To observe the related influencing factors of nonalcoholic fatty liver disease(NAFLD).Methods A total of 82 patients with NAFLD admitted to Shangrao Second People's Hospital from January 2021 to November 2023 were selected as the NAFLD group,and 50 healthy subjects during the same period were selected as the control group.The adenosine deaminase(ADA)activity,thyroid hormone(free triiodothyronine[FT3],free thyroxine[FT4])and thyroid stimulat-ing hormone(TSH)levels of the two groups were compared,and the influencing factors of NAFLD were analyzed by multi-variate logistic regression model.Results ADA activity and TSH levels in NAFLD group were higher than those in control group,and FT3 and FT4 levels in NAFLD group were lower than those in control group,the differences were statistically sig-nificant(P<0.05).Multivariate logistic regression model analysis showed that ADA activity(β=0.671.OR=1.956,95%CI:1.259-3.040),FT3(β=-0.558,OR=1.747,95%CI:1.035-2.949),FT4(β=-0.611,OR=0.543,95%CI:0.299-0.985)and TSH(β=0.447,OR=1.564,95%CI:1.138-2.148)were independent influencing factors for the occurrence of NAFLD(P<0.05).Conclusion Compared with healthy people,ADA activity and TSH levels are higher in patients with NAFLD,while FT3 and FT4 levels are lower.Moreover,ADA activity,FT3,FT4 and TSH levels are all independent influencing factors for the occurrence of NAFLD.Targeted measures should be taken to reduce the incidence of NAFLD.

Adenosine deaminaseThyroid hormoneThyroid stimulating hormoneNonalcoholic fatty liver disease

江丽慧、占燕英、余敬先

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江西省上饶市第二人民医院检验科,江西上饶 334000

江西省上饶市第二人民医院内科,江西上饶 334000

腺苷脱氨酶 甲状腺激素 促甲状腺激素 非酒精性脂肪性肝病

江西省卫生健康委科技计划项目

202410988

2024

中国当代医药
中国保健协会 当代创新(北京)医药科学研究院

中国当代医药

影响因子:1.215
ISSN:1674-4721
年,卷(期):2024.31(27)
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