丁苯酞注射液联合依达拉奉右莰醇治疗急性脑梗死的临床效果
Clinical effect of Butylphthalide Injection combined with Edaravone and Dexborneol in the treatment of acute cerebral infarction
徐旭然 1倪俊 1孙小祥1
作者信息
- 1. 南京市高淳人民医院神经内科,江苏南京 211300
- 折叠
摘要
目的 探讨丁苯酞注射液联合依达拉奉右莰醇治疗急性脑梗死的临床效果.方法 回顾性选取2022年8月至2023年8月南京市高淳人民医院神经内科诊治的72例急性脑梗死患者进行研究,依据治疗方法分为对照组(n=36)和观察组(n=36).对照组采用丁苯酞注射液治疗,观察组采用丁苯酞注射液+依达拉奉右莰醇治疗.比较两组患者治疗效果、神经功能、炎症因子、血管内皮功能指标及不良反应发生情况.结果 观察组的总有效率高于对照组,差异有统计学意义(P＜0.05).观察组患者治疗后美国国立卫生院神经功能缺损(NIHSS)评分低于对照组,差异有统计学意义(P＜0.05).观察组的超敏C反应蛋白、白细胞介素-8及肿瘤坏死因子水平均低于对照组,差异有统计学意义(P＜0.05).观察组内皮素-1低于对照组,一氧化氮高于对照组,差异有统计学意义(P＜0.05).两组的不良反应总发生率比较,差异无统计学意义(P＞0.05).结论 丁苯酞与依达拉奉右莰醇联合应用在急性脑梗死治疗中展现出良好的临床效果,在改善神经功能、炎症因子以及脑部血液灌注指标上有显著的效果,且安全性较高.
Abstract
Objective To explore the clinical effect of Butylphthalide Injection combined with Edaravone and Dexborneol in the treatment of acute cerebral infarction.Methods Seventy-two patients with acute cerebral infarction diagnosed and treat-ed in the Department of Neurology,Nanjing Gaochun People's Hospital from August 2022 to August 2023 were retrospectively selected for study,and they were divided into control group(n=36)and observation group(n=36)according to treatment methods.The control group reated with Butylphthalide Injection,the observation group treated with Butylphthalide Injection combined with Edaravone and Dexborneol.The therapeutic effect,nerve function,inflammatory factors,vascular endothelial function indexes and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).The National Institutes of Health stroke scale(NIHSS)score of observation group was lower than that of control group after treatment,and the difference was statistically significant(P＜0.05).The levels of hypersensitive C-reactive protein,inter-leukin-8 and tumor necrosis factor in observation group were lower than those in control group,and the differences were statistically significant(P＜0.05).Endothelin-1 in observation group was lower than that in control group,and nitric oxide was higher than that in control group,the differences were statistically significant(P＜0.05).There was no significant differ-ence in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion The combination of Butylph-thalide Injection and Edaravone and Dexborneol in the treatment of acute cerebral infarction has shown good clinical effects,and has significant effects on improving nerve function,in-flammatory factors and cerebral blood perfusion indexes,with high safety.
关键词
丁苯酞注射液/依达拉奉右莰醇/急性脑梗死/炎症因子Key words
Butylphthalide Injection/Edaravone and Dexborneol/Acute cerebral infarction/Inflammatory factor引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
万方数据