摘要
目的:调查非酒精性脂肪肝(NAFLD)患者生活质量现状,分析NAFLD患者生活质量水平与生活方式、体成分、肝脏弹性等影响因素的关系.方法:选取2021年9月至2023年4月在北京佑安医院脂肪肝与体重管理护理门诊就诊的215例NAFLD患者进行问卷调查、填写SF-36生活质量量表,以北京地区常模作为对照,了解NAFLD患者生活质量现状,同时进行体成分测定、肝脏弹性测定、血标本检测等.根据是否吸烟、肝脏CAP值等进行分组,分析与生活质量之间的相关性.结果:NAFLD患者总体健康、活力、精神健康、生理健康4个维度低于北京地区常模(P＜0.05);吸烟患者生理职能、社会功能、心理健康较差(P＜0.05);CAP值越高,患者总体健康、生理健康水平越差;LSM值越高,患者躯体疼痛评分越低.CAP≥248 dB/m患者的生理功能(PF)、总体健康(GH)、活力(VT)、生理健康低于CAP值＜248 dB/m组.结论:NAFLD患者生活质量处于较低水平,肝脏CAP值、LSM值、吸烟是影响生活质量的重要因素,应根据NAFLD患者具体情况尽早干预,改变生活方式、戒烟等,从而改善NAFLD患者生活质量.
Abstract
Objective:To investigate the quality of life(QOL)of patients with non-alcoholic fatty liver disease(NAFLD),and analyze its influencing factors such as lifestyle,body composition,and liver elasticity.Methods:215 patients with NAFLD were enrolled in this study.Socio-demographic data such as gender,age,education,marital status,personal monthly income,and so on were collected.Clinical tests such as complete blood count,liver function,metabolic panel,body composition,and liver stiffness measurement were conducted.QOL was measured using the Medical Outcomes Study Short Form 36(SF-36).Results:Patients with NAFLD had poorer general health(GH),vitality(VT),mental health(MH),and physical health than general people(P＜0.05).Smoking patients had poorer role-physical(RP),social functioning(SF),and mental health than non-smoking patients(P＜0.05).Patients with higher CAP values had poorer GH and physical health,and patients with higher LSM values had poorer bodily pain(BP).Conclusion:Patients with NAFLD had significantly lower QOL,and its influencing factors included liver CAP value,LSM value,and smoking.Early interventions such as lifestyle changes and smoking quitting should be taken to improve the QOL of NAFLD patients.
维普
万方数据