Objective:To analyze the colorectal cancer screening results of the 35-74-year-old medical check-up population in Beijing Donggaodi community from May 2019 to November 2020,and to provide some references for the early screening pattern of colorectal cancer.Methods:Multi-target fecal FIT-DNA combined detection technique was used for screening,and the positive population was examined by whole colonoscopy.Results:1 963 people completed the test,and the FIT-DNA positive rate was 14.0%(275/1 963),which tended to increase with age(x2 =17.990,P=0.000);the positive rate was higher in men aged 70～74 years(27.5%)than in women of the same age(15.3%),and there was no gender difference in other age groups(P＜0.000);hypertension,diabetes mellitus,frequent smoking,regular alcohol consumption,and low education groups had higher FIT-DNA positivity rates(P＜0.05).The total participation rate of colonoscopy was 9.48%(186/1 963),the participation rate of FIT-DNA-positive colonoscopy was 61.8%(170/275),and colorectal cancer and precancerous lesions were detected in 33.9%(63/186);the positive concordance rate between FIT-DNA and colonoscopy results reached 92.10%,among which the positive concordance rate between bowel cancer and high-grade lesions reached 100%;75.9%(1 489/1 963)had both FIT-DNA and iFOB,with the former being higher than the latter(x2= 39.78,P＜0.001)and the former being 2.18 times higher than the latter(OR=2.177,95%CI 1.702～2.784).Conclusion:FIT-DNA can significantly increase the participation rate of colonoscopy,which is beneficial to improve the detection of bowel cancer and precancerous lesions,and can be used as an effective means for early screening of colorectal cancer in community population.
维普
万方数据