摘要
目的:本研究旨在探讨绝经后女性和50岁及以上男性甘油三酯葡萄糖指数(TyG)与骨密度(BMD)之间的相关性.方法:本研究回顾性分析了中南大学湘雅二医院体检人群中2 911例受检者(1 470例年龄≥50岁的男性和1 441例绝经后女性)的数据.使用双能X射线(DXA)测量了腰椎BMD、股骨颈BMD和全髋BMD.根据TyG指数按四分位数法分为四组.采用多元线性回归分析TyG指数与BMD之间的关联.并按性别对进行了亚组分析.结果:随着TyG指数的升高,年龄、BMI、肌酐、空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、尿酸水平、血清钙、总腰椎BMD、股骨颈BMD、总髋BMD均升高.在多元线性回归分析中,在矫正了年龄、性别、既往骨折史、父母髋部骨折史、吸烟、糖皮质激素使用史、类风湿关节炎、继发性骨质疏松、过量饮酒、体质量指数、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、尿酸、肌酐、血清钙、血清磷、25(OH)D等危险因素后,TyG指数和骨密度没有相关性.按性别进行亚组分析后,男性的腰椎BMD、股骨颈BMD、总髋BMD与TyG呈正相关性,但不成线性关系.结论:50岁及以上男性中,TyG指数与腰椎BMD、股骨颈BMD、总髋BMD呈正相关,TyG指数可能成为骨质疏松预防和治疗的监测指标.
Abstract
Purpose:This study aimed to explore the correlation between the triglyceride-glucose index(TyG)and bone mineral density(BMD)in postmenopausal women and men aged 50 and above.Methods:Data from 2 911 participants(including males aged≥50 years and postmenopausal females)were retrospectively analyzed at the Xiangya Second Hospital of Central South University.Dual-energy X-ray absorptiometry(DXA)was used to measure lumbar spine BMD,femoral neck BMD,and total hip BMD.Participants were divided into four groups based on TyG index quartiles.Multiple linear regression analysis was used to assess the association between TyG index and BMD,with subgroup analysis by gender.Results:With increasing TyG index,age,BMI,creatinine,fasting blood glucose,total cholesterol,triglycerides,low-density lipoprotein,uric acid levels,serum calcium,lumbar spine BMD,femoral neck BMD,and total hip BMD all increased.However,after adjusting for various risk factors,including age,gender,history of prior fractures,parental hip fracture history,smoking,glucocorticoid use history,rheumatoid arthritis,secondary osteoporosis,excessive alcohol consumption,body mass index,total cholesterol,high-density lipoprotein,low-density lipoprotein,uric acid,creatinine,serum calcium,serum phosphorus,and 25(OH)D,there was no correlation between TyG index and BMD.Subgroup analysis by gender showed a positive correlation between TyG index and lumbar spine BMD,femoral neck BMD,and total hip BMD in males,but the relationship was not linear.Conclusion:This study demonstrates a positive correlation between TyG index and lumbar spine BMD,femoral neck BMD,and total hip BMD in males aged 50 and above.The TyG index could serve as an effective indicator for the prevention and treatment of osteoporosis.
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