摘要
目的:调查株洲地区40岁以上健康体检人群动脉硬化患病情况,以及株洲地区血压、血脂对动脉硬化的影响.方法:本研究为横断面研究,选择2022年10月至2023年2月在株洲市二医院健康管理中心40岁以上健康受检者作为研究对象,分析动脉硬化的检出情况;采用ANOVA分析、t检验或Wilcoxon秩和检验分析年龄、身高、体质量、体质量指数(BMI)、收缩压、舒张压、胆固醇、低密度脂蛋白胆固醇及甘油三酯对动脉硬化的影响,有差异性的风险因素进行相关性分析,最后通过二项Logistic回归分析相关危险因素对动脉硬化的影响大小.结果:不同年龄组的动脉硬化检出率不断增高(P＜0.05).60岁以前,男性动脉硬化检出率高于女性;60岁以后,男、女之间动脉硬化检出率无差异.年龄、身高、收缩压、舒张压在动脉正常组和动脉硬化组之间差异有统计学意义(P＜0.05),其中年龄及收缩压与动脉硬化有强相关关系.二项Logistic回归分析显示,收缩压(OR 1.121,95%CI 1.092～1.150)和舒张压(OR 1.102,95%CI 1.071～1.133)均为动脉硬化的危险因素;对年龄、身高、体质量、BMI、血脂相关指标进行校正后,收缩压(OR 1.108,95%CI 1.076～1.140)及舒张压(OR 1.139,95%CI 1.096～1.183)仍与动脉硬化显著相关.结论:株洲地区40岁以上健康体检人群中的动脉硬化患病率不断上升.血压是影响动脉硬化的主要危险因素,血脂对动脉硬化无明显影响.
Abstract
Objective:Investigate the prevalence of arteriosclerosis in healthy individuals above 40 years old in Zhuzhou area,as well as the impact of hypertension and dyslipidemia on arteriosclerosis in Zhuzhou area.Methods:It is a cross-sectional study.Select 400 healthy individuals above 40 years old who underwent physical examination at the Health Management Center of Zhuzhou Second Hospital from October 2022 to February 2023 as the research subjects to analyze the detection of arteriosclerosis.ANOVA analysis,t-test,or Wilcoxon rank sum test was used to analyze the effects of age,height,weight,BMI,systolic blood pressure,diastolic blood pressure,cholesterol,low-density lipoprotein,and triglycerides on arteriosclerosis.Correlation analysis was conducted on risk factors with differences.Finally,binomial logistic regression was used to analyze the impact of relevant risk factors on arteriosclerosis.Results:The detection rate of arteriosclerosis continues to increase in different age groups(P＜0.05).Before the age of 60,the detection rate of arteriosclerosis in males is higher than that in females;After the age of 60,there is no difference in the detection rate of arteriosclerosis between males and females.There were statistically significant differences in age,height,systolic and diastolic blood pressure between the normal control group and the arteriosclerosis group(P＜0.05).And there is a strong correlation between age,systolic blood pressure and arteriosclerosis.Binomial logistic regression analysis showed that systolic blood pressure,and diastolic blood pressure were both risk factors for arteriosclerosis;After adjusting for age,height,weight,BMI,and blood lipid indicators,systolic blood pressure and diastolic blood pressure were still significantly correlated with arteriosclerosis.Conclusion:The prevalence of arteriosclerosis is continuously increasing among the population aged 40 and above in Zhuzhou.In this study,age,systolic blood pressure,and diastolic blood pressure were risk factors affecting arteriosclerosis,with age having the greatest impact on arteriosclerosis,followed by systolic hypertension,and dyslipidemia having no significant impact on arteriosclerosis.
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