TyG-BMI指数对颈动脉粥样硬化进展的预测作用:一项前瞻性队列研究结果

TyG-BMI Index as a Predictor of Carotid Atherosclerosis Progression:A Prospective Cohort Study

刘娟 ¹郝小燕 ¹何宏海 ¹王媛媛 ¹王阳 ¹陶立元 ²徐顺霖 ³王鹏 ¹赵威⁴

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作者信息

1. 北京大学第三医院体检中心,北京 100191
2. 北京大学第三医院临床流行病学研究中心,北京 100191
3. 北京大学第三医院心内科,国家卫生健康委心血管分子生物学与调节肽重点实验室,分子心血管学教育部重点实验室,心血管受体研究北京市重点实验室,北京 100191
4. 北京大学第三医院体检中心,北京 100191;北京大学第三医院心内科,国家卫生健康委心血管分子生物学与调节肽重点实验室,分子心血管学教育部重点实验室,心血管受体研究北京市重点实验室,北京 100191
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摘要

目的:本研究旨在分析甘油三酯葡萄糖-体质量指数(TyG-BMI)对颈动脉粥样硬化进展的影响,为临床实践和心血管疾病防控提供参考.方法:本研究为基于北京大学第三医院健康体检人群的前瞻性队列研究,共纳入9 525例受检者,中位随访时间为755d.研究将TyG-BMI作为暴露因素,研究终点事件为颈动脉粥样硬化进展.使用Cox比例风险回归模型分析TyG-BMI对颈动脉粥样硬化进展速度的影响.结果:研究显示,TyG-BMI与颈动脉粥样硬化进展存在显著相关性.在未矫正混杂因素的情况下,TyG-BMI高值组的颈动脉粥样硬化进展风险比低值组显著增加(HR=1.5,95%CI 1.3～1.7,P＜0.001).在矫正性别、年龄、高血压、糖尿病、高脂血症、收缩压、舒张压、心率、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)混杂因素后,TyG-BMI高值组仍表现出较高的颈动脉粥样硬化进展风险(HR=1.3,95%CI 1.1～1.5,P＜0.001).结论:TyG-BMI数值较高的人群颈动脉粥样硬化进展风险显著增加,即使在调整多种心血管危险因素后,TyG-BMI对颈动脉粥样硬化进展的影响依然显著.TyG-BMI可考虑作为预测心血管事件的潜在指标,在临床早期筛查和风险评估中应用.

Abstract

Objective:This study aimed to analyze the impact of the triglyceride-glucose-body mass index(TyG-BMI)on carotid atherosclerosis progression,providing reference for clinical practice and cardiovascular disease prevention.Methods:This prospective cohort study included 9 525 participants from the health checkup population at Peking University Third Hospital,with an average follow-up of 755 days.TyG-BMI was used as the exposure factor,and the study endpoint was the carotid atherosclerosis progression.Cox proportional hazards regression models were used to analyze the impact of TyG-BMI on carotid atherosclerosis progression.Results:The study showed a significant association between TyG-BMI and carotid atherosclerosis progression.In the unadjusted model,the high TyG-BMI group had a significantly increased risk of carotid atherosclerosis progression compared to the low TyG-BMI group(HR=1.5,95%CI 1.3-1.7,P＜0.001).After adjusting for confounders such as sex,age,hypertension,diabetes,hyperlipidemia,SBP,DBP,HR,TC,LDL-C and HDL-C,the high TyG-BMI group still exhibited a higher risk of carotid atherosclerosis progression(HR=1.3,95%CI 1.1-1.5,P＜0.001).Conclusion:The results indicate that individuals with higher TyG-BMI have a significantly increased risk of carotid atherosclerosis progression.Even after adjusting for multiple cardiovascular risk factors.TyG-BMI may serve as a potential indicator for predicting cardiovascular events,with implications for early clinical screening and risk assessment.

关键词

甘油三酯-葡萄糖指数/体质量指数/胰岛素抵抗/颈动脉粥样硬化进展/风险评估

Key words

Triglyceride glucose index/Body mass index/Insulin resistance/Carotid atherosclerosis progression/Risk assessment

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出版年

2024

健康体检与管理

中国医院协会

健康体检与管理

ISSN：2096-9449

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