Objective Analyze the adverse events following immunization(AEFI)data in Huzhou City and compare the AEFI incidence rate of DTaP-IPV/Hib、PPV23、DTaP、MR、MMR、VarV、JE-L、MPV-A、DT vaccines to explore the influencing factors of AEFI risk,in order to provide reference basis for further AEFI monitoring and vaccination work.Methods Data on AEFI for nine vaccines administered between 2015 and 2019 in the AEFI surveillance management system in Huzhou City were collected.Descriptive methods were used to analyze the occurrence of AEFI,and binary logistic regression models were used to identify factors influencing the risk of AEFI.Results The cumulative incidence of AEFI for the nine vaccines was 58.36 per 100,000.The highest incidence of AEFI was reported for the DTaP-IPV/Hib vaccine at 158.21 per 100,000.The multifactorial logistic regression analysis revealed that the risk of local erythema was higher with MPV-A vaccination(OR=3.298,95%CI:1.224-8.886,P=0.018).The risk of local induration was higher in females(OR=1.36,95%CI:1.046-1.769,P= 0.022),those aged 1 to 4 years(OR= 2.885,95%CI:1.011-8.232,P= 0.048),and those with injections in the right upper arm(OR= 3.888,95%CI:1.018-14.853,P= 0.047).The time intervals between vaccination with MPV-A and the appearance of AEFI were as follows:5.750(3.000,11.978)hours for those vaccinated at less than 1 year of age,7.18(4.000,23.130)hours for those vaccinated after the 1st dose,and 8.17(4.32,24.00)hours for those vaccinated after subsequent doses.The shortest time intervals between vaccination with MPV-A,<1 year of age,and after the 1st dose of vaccination to the appearance of AEFI were 5.750(3.000,11.978),7.18(4.000,23.130),and 8.17(4.32,24.00)hours,respectively.The differences in the time to AEFI by vaccine,age,and dose were statistically significant(all P<0.001).Conclusions Adverse reactions to vaccination can be influenced by various factors,such as age,gender,and vaccination site.To ensure the safety of vaccination,it is recommended to use a combination of active and passive monitoring to promptly detect and address any adverse reactions.
vaccineimmunizationadverse events following immunizationinfluencing factor
国家科技期刊平台
NSTL
万方数据
