Observations on sdLDL-C and Lp-PLA2 levels in patients with acute cerebral infarction with different properties of carotid atheromatous plaques and prognosis
Objective To investigate the levels of small and dense low-density lipoprotein cholesterol(sdLDL-C)and lipoprotein-associated phospholipase A2(Lp-PLA2)in patients with acute cerebral infarction and their relationship with carotid atherosclerotic plaque stability.The study aims to provide ideas for early identification and improvement of patients'prognosis.Methods The study analysed the results of cervical vascular ultrasound examination of plaque characteristics in 164 patients with ACI(observation group).Of these,49 had no plaque,58 had stable plaque,and 57 had unstable plaque.The control group consisted of 47 healthy individuals undergoing physical examinations.The study compared the levels of homocysteine(Hcy),sdLDL-C,and Lp-PLA2 expression between the two groups.The study recorded the National Institutes of Health Stroke Scale(NIHSS)scores for the patients and evaluated their prognosis during the 30-day follow-up period.Additionally,the factors that affect the prognosis of acute cerebral infarction(ACI)were analyzed.Results In patients with acute coronary ischemia(ACI),fasting blood glucose(PBG),triglycerides(TG),sdLDL-C/LDL-C,sdLDL-C/TC,and Lp-PLA2 levels were higher than those in the control group.Additionally,HDL-C levels were lower in the patient group.Among patients with plaque,Hcy and sdLDL-C levels were higher than those without plaque and the control group.Patients with unstable plaque had higher levels of TC and LDL-C than those without plaque and the control group,with significant differences(P<0.05).The rate of unstable plaques detected in the poor prognosis group(45.78%)is higher than that in the good prognosis group(23.46%).The admission NIHSS score,blood glucose,sdLDL-C,sdLDL-C/LDL-C,sdLDL-C/TC,and Lp-PLA2 levels were all significantly higher in the poor prognosis group than in the good prognosis group(P<0.05).Conclusions The levels of sdLDL-C and Lp-PLA2 are closely related to the stability of carotid artery plaques in patients with ACI.They also have positive implications for prognosis assessment.
small dense low-density lipoprotein-cholesterollipoprotein-Associated phospholipase A2acute cerebral infarctionnational institutes of health stroke scalecarotid artery plaqueprognosis
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