Objective To explore the related risk factors for hypothermia in premature infants upon hospital admission,and to provide insights for clinical interventions.Methods The clinical data of 253 preterm infants were retrospectively analyzed.The infants were categorized into two groups based on their body temperature at admission:the hypothermia group(n= 122)and the normal temperature group(n=131).The factors affecting the occurrence of hypothermia were analyzed by Logistic regression,and the correlation analysis was carried out by Spearman method.Results The two groups of infants showed statistically significant differences in terms of gestational age,birth weight,presence of birth asphyxia,infection,neonatal respiratory distress syndrome,premature rupture of membranes,and singleton or multiple births(P<0.05).Logistic regression analysis revealed that birth weight<2 500 g,occurrence of infection,and multiple births were factors associated with the occurrence of hypothermia in infants(P<0.05).Gestational age and birth weight were negatively correlated with the occurrence of hypothermia(r=-0.251,-0.748,P<0.05),while the presence of birth asphyxia,infection,neonatal respiratory distress syndrome,premature rupture of membranes,and singleton or multiple births were positively correlated with the occurrence of hypothermia(all P<0.05).Infant body temperature at admission was negatively correlated with the occurrence of asphyxia,infection,and neonatal respiratory distress syndrome(r=-0.257,-0.399,-0.392,P<0.05),but showed no correlation with hypoglycemia(P>0.05).Conclusions Risk factors for the occurrence of hypothermia in infants include low birth weight,infection,and multiple births.Furthermore,infants with lower body temperatures are at a higher risk of developing asphyxia,infection,and neonatal respiratory distress syndrome.Clinically,effective management of infant body temperature should be implemented based on individual circumstances to improve prognosis.