Objective To observe and compare the mid-to long-term prognosis of moderate lobar cerebral hemorrhage treated with conservative treatment and endoscopic-assisted surgery,providing clinical reference.Methods A total of 205 patients with moderate lobar cerebral hemorrhage were divided into a conservative treatment group(113 cases)and an endoscopic surgery group(92 cases)according to their treatment methods.The length of hospital stay within 1 month,duration of cerebral edema,and maximum volume of cerebral edema were collected and compared between the two groups to evaluate short-term prognosis.The activity of daily living(ADL)score and mini-mental state examination(MMSE)were used to evaluate the prognosis of patients at 3 and 6 months after treatment.Results There were statistically significant differences in hospital stay,duration of brain edema,and maximum volume of brain edema between the conservative treatment group and the endoscopic surgery group(P<0.05).Within 1 month of treatment,the conservative treatment group had 29 cases of pulmonary infection,73 cases of electrolyte imbalance,25 cases of cerebral infarction,and 43 cases of lower extremity venous thrombosis,while the endoscopic surgery group had 11 cases,70 cases,10 cases,and 20 cases,respectively.There was no statistically significant difference in the occurrence of electrolyte imbalance between the two groups(χ2=3.17,P=0.075),but the occurrence of pulmonary infection,cerebral infarction,and lower extremity venous thrombosis showed statistical significance(all P<0.05).At 1,3,and 6 months after treatment,the endoscopic surgery group had higher GCS scores compared to the conservative treatment group.At 3 and 6 months after treatment,the endoscopic surgery group had higher ADL scores and MMSE scores compared to the conservative treatment group.The differences were statistically significant(P<0.05).Conclusions Endoscopic surgery for moderate lobar cerebral hemorrhage has been found to result in better long-term independent living ability and cognitive function compared to conservative treatment.