Objective To investigate the mediating effect of work engagement among intensive care unit(ICU)nurses on resourcefulness and depression,and to provide a basis for the development of targeted intervention measures.Methods A questionnaire survey was conducted in among 1 478 ICU nurses from six top-grade tertiary hospital in Henan Province by using the depression subscale of the depression-anxiety-stress scales(DASS),the resourceability scale and work involvement scale.Pearson correlation analysis was applied to investigate the relationships among these variables,and structural equation modeling with Amos 24.0 was utilized to analyze the pathways of influence.Results A total of 1 478 ICU nurses participated in the study with mean scores of(81.27±8.58)points on the resourcefulness scale,(55.98±5.46)points on the work engagement scale,and(11.51±1.68)points on the depression scale.Pearson correlation analysis revealed a positive correlation between work engagement and resourcefulness among ICU nurses(r=0.227,P<0.001),while depression showed a significant negative correlation with both resourcefulness(r=-0.339,P<0.001),and work engagement(r=-0.466,P<0.001).Bootstrap analysis indicated that resourcefulness and work engagement have significant negative predictive effects on depressive symptoms(β=-0.260 for resourcefulness and β=-0.451 for work engagement,all P<0.001).Work engagement partially mediated the relationship between resourcefulness and depressive mood,with a mediating effect value of-0.083,accounting for 24.2%of the total effect.Conclusions The work engagement of ICU nurses serves as a mediating variable between resourcefulness and depressive emotions.Nursing managers can improve the resourcefulness level of ICU nurses and increase their work involvement,so as to reduce the incidence of depression.