摘要
目的 了解淋巴瘤化疗患者的经济毒性水平并分析其影响因素,为改善患者预后提供思路.方法 收集 140例淋巴瘤化疗患者的病历资料,采用患者报告结局的经济毒性综合评分量表进行横断面调查,应用多元线性回归分析探究影响淋巴瘤患者经济毒性的相关因素.结果 淋巴瘤化疗患者的经济毒性总分为(20.27±6.99)分,其中106 例(75.71%)存在经济毒性;不同年龄、婚姻状况、医保类型、目前工作状态、诊断前工作状态、子女数量、子女经济独立情况、家庭人均月收入、家庭可支配存款、应用新型抗肿瘤药物、移植或免疫治疗的淋巴瘤化疗患者间,经济毒性总分差异有统计学意义(P<0.05).多元线性回归结果显示,新型农村合作型医保、诊断前处在失业状态、家庭可支配存款少、应用新型抗肿瘤药物、进行移植或免疫治疗均为淋巴瘤化疗患者经济毒性的危险因素(P<0.05),可解释总变异的 51.3%.结论 大部分淋巴瘤化疗患者存在经济毒性,主要与医保类型、工作状态、经济状况相关.建议临床尽早评估患者的经济毒性水平,选择个体化的治疗方案以改善预后.
Abstract
Objective To understand the current status of economic toxicity in lymphoma chemotherapy patients and analyzing its influencing factors,so as to provide insights for improving patient prognosis.Methods A total of 140 patients undergoing lymphoma chemotherapy were enrolled in this study.The clinical data of patients were collected.A cross-sectional survey was conducted using the patient-reported outcomes measurement information system-economic toxicity composite score(PROMIS-EC)to assess the economic burden.Multivariate linear regression analysis was applied to investigate the factors associated with economic toxicity in lymphoma patients.Results The total economic toxicity score for lymphoma chemotherapy patients was(20.27±6.99)points,with 106 cases(75.71%)experiencing economic toxicity.Differences in economic toxicity scores were found among patients of different ages,marital statuses,types of medical insurance,current employment status,pre-diagnosis employment status,number of children,financial independence of children,average monthly household income,disposable savings,use of novel anti-tumor drugs,and those undergoing transplantation or immunotherapy,with statistical significance(all P<0.05).Multivariate linear regression results indicated that the new rural cooperative medical system insurance,unemployment status prior to diagnosis,limited disposable family savings,use of novel antitumor drugs,and undergoing transplantation or immunotherapy were all risk factors for economic toxicity in lymphoma chemotherapy patients(all P<0.05),accounting for 51.3%of the total variability.Conclusions Most lymphoma chemotherapy patients experience economic toxicity,primarily associated with the type of medical insurance,employment status,and financial situation.It is recommended that clinicians assess patients'levels of economic toxicity early on and select personalized treatment plans to improve prognosis.
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