Objective To evaluate the effect of Helicobacter pylori(Hp)on the clinical manifestations and outcomes of SARS-CoV-2 infection.Methods Patients undergoing C14 breath test or rapid urease test for Hp infection in the hospital were selected for investigation.The study aims to understand the clinical presentation of COVID-19 in patients with prior Hp infection,the time frame for significant improvement in symptoms of COVID-19,and to collect data on Hp infection status and basic socio-demographic information of the patients.The survey included the clinical manifestations of SARS-CoV-2,the time to significant symptom improvement among those with a history of SARS-CoV-2 infection,Hp infection status and basic sociodemographic information.Results A total of 502 patients with a history of SARS-CoV-2 infection were surveyed,including 189 Hp-positive and 313 Hp-negative cases.The incidence of abdominal pain(12.2%),abdominal distension(10.1%),and diarrhea(34.9%)in Hp-positive patients were significantly higher than those in Hp-negative patients(5.1%,3.5%,24.3%,respectively),with all differences being statistically significant(P<0.05).Among Hp-negative patients,28.8%had negative conversion of SARS-CoV-2 nucleic acid/antigen within one week,while among Hp-positive patients,only 6.3%had negative conversion within the same period,showing a statistically significant difference(P<0.05);There was no statistically significant differences in the proportion of patients with significant symptom improvement within three days after contracting SARS-CoV-2 between Hp-positive(25.4%)and-negative patients(31.0%)(=1.795,P=0.180).Conclusions Compared to Hp-negative patients,Hp-positive patients had higher rates of abdominal pain,diarrhea,and bloating after contracting SARS-CoV-2.The presence of Hp significantly influenced the time for SARS-CoV-2 antigen or nucleic acid conversion to negative,but did not affect the time for symptom relief.
SARS-CoV-2Helicobacter pyloridigestive system symptoms
国家科技期刊平台
NSTL
万方数据
