Objective To observe the effects of non-inflatable dual-port transaxillary endoscopic surgery and open radical surgery for thyroid cancer on patients'inflammatory stress response and aesthetic outcomes,and to analyze the factors related to postoperative complications.Methods A total of 98 patients with thyroid cancer were included,with 49 patients treated with open radical thyroidectomy(control group)and 49 patients treated with non-inflatable dual-port transaxillary endoscopic surgery(observation group).The surgical status,levels of inflammatory markers,aesthetic outcomes,and incidence of postoperative complications were statistically analyzed and compared between the two groups.Logistic regression analysis was used to determine the factors influencing the occurrence of postoperative complications in patients.Results The observation group had higher intraoperative blood loss,longer operation time,and greater drainage fluid volume compared to the control group.The levels of procalcitonin(PCT)and interleukin 6(IL-6)on the third day of treatment were higher in both groups compared to pre-treatment levels,with the observation group showing lower levels than the control group.The aesthetic satisfaction was higher in the observation group than in the control group,with statistically significant differences(P<0.05).Among the 98 patients,14 cases experienced complications,resulting in a complication rate of 14.29%.Logistic regression analysis revealed that age over 45 years,tumor diameter≥2 cm,and high preoperative PCT levels were influencing factors for postoperative complications in patients(P<0.05).Conclusions Compared to open radical thyroidectomy,non-inflatable dual-port transaxillary endoscopic surgery can reduce inflammatory marker levels and provide better cosmetic results.Patients over 45 years old,with a tumor diameter exceeding 2 cm,and with high preoperative PCT levels are more likely to experience postoperative complications.