Objective To explore the effect of post-discharge follow-up on the recovery of patients with early gastric mucosal lesions undergoing endoscopic submucosal dissection(ESD),and to provide a basis for patient self-management.Methods A total of 98 patients who underwent gastric ESD were divided into two groups:the control group(49 cases)received routine postoperative follow-up and the observation group(49 cases)received regular follow-up after discharge.After one month of follow-up,the psychological status,sleep quality,pain levels,and incidence of adverse reactions before and after discharge were compared between the two groups.Results At one month post-discharge the observation group showed significantly better improvement in scores for pain,the self-rating anxiety scale(SAS),the self-rating depression scale(SDS),the coping style questionnaire(CSQ),the symptom checklist-90(SCL-90),and the Pittsburgh sleep quality index(PSQI)compared to the control group,with all differences being statistically significant(all P<0.05).The incidence of adverse reactions in observation group(12.24%)was lower than that in control group(32.65%),and the difference was statistically significant(χ2=5.861,P=0.016).Conclusions Enhancing post-discharge follow-up for patients after gastric ESD can effectively improve patients'sleep quality and negative emotions,as well as reduce adverse reactions.