Construction of dietary patterns for patients with head and neck squamous cell carcinoma based on Gaussian graphical models and its relationship with disease risk
Objective To construct a dietary pattern network for patients with head and neck squamous cell carcinoma using Gaussian graphical models(GGM),and to explore its relationship with the risk of head and neck squamous cell carcinoma.Methods A case-control study design was employed,utilizing a simplified version of the food frequency questionnaire(FFQ25)to conduct a survey among 121 pathologically confirmed primary head and neck squamous cell carcinoma patients and 242 individuals without head and neck squamous cell carcinoma during the same period.The dietary pattern network scores for each study subject were calculated based on the intensity of centrality index and dietary intake.Multivariate Logistic regression was used to analyze the relationship between the dietary pattern network score and the risk of head and neck squamous cell carcinoma.Results Based on the GGM,one primary dietary pattern network was identified:the vegetable and river type model.After adjusting for confounding factors,it was found that the vegetable and river type pattern was associated with a reduced risk of head and neck squamous cell carcinoma(OR=0.121,95%CI=0.052～0.28,P<0.001).Conclusions The vegetable-river fish dietary pattern constructed using the GGM can reduce the risk of head and neck squamous cell carcinoma.Future prospective population-based studies should be conducted to validate the association between dietary intake and the risk of head and neck squamous cell carcinoma.
head and neck squamous cell carcinomadietary patternsGaussian graphical modelsnetwork analysis
国家科技期刊平台
NSTL
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