Objective To systematically evaluate the overall risk of Epstein-Barr virus(EBV)in oral lichen planus(OLP)disease to provide a basis for the clinical treatment and prevention of OLP.Methods A database search was conducted for publications in both Chinese and English from the inception of the database until July 31,2023.Case-control studies or cross-sectional studies that met the eligibility criteria were included,and the quality of the literature was assessed.The RevMan 5 software was used to perform a Meta-analysis of the included literature.The pooled odds ratio(OR)and 95％confidence interval(95％CI)were estimated to determine the association between EBV infection and OLP using a fixed-or random-effects model based on heterogeneity.Publication bias was assessed using funnel plot analysis.Results A total of 9 case-control studies were included,involving 438 patients with OLP and 294 healthy controls.The Meta-analysis demonstrated a significant association between Epstein-Barr virus(EBV)infection and OLP,with an OR value of 4.72(95％CI:3.06-7.29),and the combined effect Z-value is 6.99(P＜0.001).There is a significant geographical population difference in the correlation between EBV and OLP.Conclusions The results of the current Meta-analysis suggest that EBV infection is statistically associated with increased risk of OLP.The strength of the association may be influenced by geographical and population factors.
万方数据
维普
