Objective To investigate the risk factors for the occurrence of agoraphobia in patients after Percutaneous coronary intervention(PCI)for coronary artery disease,and to construct a relevant prediction model to provide a basis for early clinical identification and intervention of agoraphobia after PCI.Methods This paper was a cross-sectional survey,the clinical data of 141 post-coronary PCI patients were collected,and they were divided into the agoraphobia group(47 cases)and the non-agoraphobia group(94 cases)according to whether or not agoraphobia occurred,and the data of the 2 groups of patients were compared.Multivariate Logistic regression analysis was utilized to identify the risk factors associated with the development of agoraphobia post-PCI.A predictive model was developed,and the predictive value of this model for agoraphobia in post-PCI patients was assessed using the receiver operating characteristic(ROC)curve analysis.Results Comparison of heart failure,family functioning,and self-perceived burden,as well as pain level,fatigue level,and social support level between the agoraphobia group and the non-agoraphobia group showed statistically significant differences(P<0.05).Logistic regression analysis showed that heart failure(OR=4.104),severe family dysfunction(OR=8.542),severe self-perceived burden(OR=4.043),severe/very severe pain(OR=6.600),severe/very severe fatigue(OR=4.702),and low social support(OR=3.963),were independent risk factors for the occurrence of agoraphobia in patients with coronary artery disease after PCI(all P<0.05).The ROC curve analysis indicated that the predictive model had a good predictive value for agoraphobia in post-PCI patients:when logit(P)>11.23,the Area Under the Curve(AUC)value was 0.926,the sensitivity was 87.23%,and the specificity was 89.36%.Conclusions The occurrence of agoraphobia in patients after PCI for coronary artery disease were related to heart failure,family dysfunction,self-perceived burden,pain level,fatigue level,and social support level.Clinically,targeted intervention measures can be developed based on these factors to prevent the onset of agoraphobia in patients with coronary artery disease after PC1.