After the end of the Cold War,against the background of easing relations between major powers,East Asia regional cooperation has embarked on a new track of open regionalism.However,after more than thirty years of development,with the rise of the strategic game between China and the United States,the parallel advancement of the U.S.Indo-Pacific strategy and China's Belt and Road Initiative has led to the open regionalist cooperation model of East Asia cooperation facing strategicization and new challenges of politicization.To solve the problem,China-ASEAN regional cooperation should adhere to genuine multilateralism,promote the transformation from an open regionalism model to a multi-stakeholder model,and promote the construction of a regional development community,a regional se-curity community,and a regional cultural community,which is a new path to promote the future construction of China-ASEAN regional cooperation architecture.