Through the determination of various physiological indicators and aging related genes,the effect of water extract of red ginseng(RGWE)on the lifespan of Caenorhabditis elegans(C.elegans)and its possible mechanism were observed.C.elegans was cultured in the normal media containing different concentrations(0.8,1.4 and 2.0 mg/mL)of RGWE medium,and explored the effect of RGWE on life,heat stress,oxidative stress,ROS content and lipofuscin content.qRT-PCR was used to determine the expression level of anti-aging related genes,and the anti-aging mechanism of RGWE was initially explored.RGWE can significantly prolong the life-span of nematodes,improve anti-stress ability,reduce lipofuscin levels and ROS levels,and up-regulate significantly the expres-sion level of daf-16 and sir2.1 genes.
维普
万方数据