Rice stem borer Chilo suppressalis is one of the major pests in rice crop,causing serious damage to rice production in China every year.At present,using chemical insecticides is still the pri-mary strategy for controlling C.suppressalis.However,due to the unreasonable use of insecticides,C.suppressalis populations in many areas of China have developed various levels of resistance to a va-riety of insecticides including organophosphorus,macrolides and anthranilic diamides.Studies on the resistance mechanisms of C.suppressalis showed that the enhanced activities of detoxifying en-zymes such as P450s and ESTs,mutations of AChEs and RyRs,and the increased transport capacity of ABC transporters mainly contributed to the resistance of C.suppressalis to insecticides.The pres-ent review summarized the resistance development and mechanisms of C.suppressalis to several com-monly used insecticides in China,in order to provide medication guidance for using insecticides to control C.suppressalis in China.