Response surface methodology(RSM)was used to study the optimal compatibility ratio and extraction process of Radix Platycodi-Radix et Rhizoma Glycyrrhizae in Jie-geng decoction(JGD).DPPH was used to compare the antioxidant capacity of extracts from different compatibility ra-tios of JGD.With solid-liquid ratio,extraction time and extraction frequency as independent vari-ables,based on the results of single-factor experiment,and with the total contents of glycyrrhizin,lo-betyolin,platycodin D and glycyrrhizin as response values,Box-Behnken RSM was adopted to opti-mize the extraction process with the optimal proportion.The results showed that JGD extracts had better scavenging effect on DPPH,among which 1∶2 ratio had the strongest scavenging effect,with an IC50 value of 0.444 mg/mL.The response surface results showed that when solid-liquid ratio was 1∶22(g∶mL),extraction time was 1.3 h,and extraction was performed three times,the content of the above index components was the highest.In conclusion,through in vitro antioxidant capacity,the op-timal compatibility ratio of JGD has been explored and the extraction process has been optimized,so as to provide theoretical support for further development and clinical application of it.
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