磁性灵芝孢子的制备及其缓释性能研究
Preparation and Sustained-release Properties of Magnetic Gano-derma Lucidum Spores
陈玉宁 1申晓彤 2韩斌 3李景梅2
作者信息
- 1. 吉林师范大学辽源分院,辽源 136200
- 2. 长春理工大学生命科学技术学院,长春 130022
- 3. 长春理工大学生命科学技术学院,长春 130022;长春理工大学国家纳米操纵与制造国际联合研究中心,长春 130022
- 折叠
摘要
以天然高分子材料灵芝孢子(Ganoderma lucidum spore,GLS)为模板,经丙酮脱脂、氢氧化钾溶液和正磷酸溶液处理后,发现GLS外壁孔隙明显变多且孔径增大,从扫描电镜图像中可以观察到内壁平整光滑,并形成内外贯通的孔道.随后,利用化学共沉淀法沉积Fe3O4纳米粒子,并通过一系列表征手段对制备的磁性灵芝孢子(Magnetic Ganoderma lucidum spore,MGLS)进行分析,探究了MGLS负载罗丹明B(Rhodamine B,RhB)后的体外释放过程.结果表明:测试6,24,48 h时,累积释放率分别为47.3%,88.4%和92.3%.这说明MGLS作为药物释放载体对RhB具有明显的缓释效果.
Abstract
Using natural polymer material Ganoderma lucidum spores(GLS)as the template,after treatment with acetone degreasing,potassium hydroxide solution and orthophosphoric acid solution,it was found that the pores in the outer wall of GLS become more and larger.From the SEM images,it was observed that the inner wall was flat and smooth,and formed internal and external channels.Then,Fe3O4 nanoparticles were deposited by chemical coprecipitation method,and the prepared MGLS was analyzed by a series of characterization methods.The in vitro release process of MGLS loaded with Rhodamine B(RhB)was investigated.It was found that at 6,24 and 48 hours of testing,the cumulative release reached 47.3%,88.4%and 92.3%,respectively.The results show that MGLS,as a drug delivery carrier,has a significant sustained-release effect on RhB.
关键词
灵芝孢子/Fe3O4纳米粒子/表征分析/罗丹明B/缓释性能Key words
Ganoderma lucidum spore/Fe3O4 nanoparticle/characterization analysis/rhodamine B/sustained release property引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据