The correlation between epicardial fat thickness and risk factors of cardiovascular disease in patients with systemic lupus erythematosus
Objective:To investigate the change of epicardial fat thickness(EFT)in patients with systemic lupus erythematosus(SLE)and its correlation with cardiac ultrasound parameters and traditional cardiovascular risk factors.Methods:SLE patients admitted to Rheumatology and Immunology Department of the First Affiliated Hospital of Jinan University from October 2019 to October 2021 were included as the case group,and healthy subjects in the same period were included as the control group.EFT was measured in both groups.SLE patients were divided into two subgroups according to whether EFT was thickened.The differences in inflammatory indicators,cardiac ultrasound parameters and traditional cardiovascular risk factors between the two subgroups were compared.Logistic regression analysis was used to explore the risk factors for EFT thickening.Results:The EFT of SLE patients was significantly thicker than that of the control group[4.40(2.60)mm vs.3.10(1.60)mm,P<0.001].EFT thickening occurred in 42.0%(76/131)of SLE patients and 9.5%(9/95)of healthy controls.The age,body mass index(BMI),left atrial diameter(LAD),right ventricular inner diameter(RVD),interventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT)and carotid intima-media thickness(CIMT)in the EFT thickening group were significantly higher than those in the non-thickening group.EFT was positively correlated with age,disease course,BMI,triglyceride,low-density lipoprotein,LAD,RVD,IVST,LVPWT and CIMT.Logistic regression analysis demonstrated that increased LVPWT was a risk factor for EFT thickening.Conclusion:EFT thickening in SLE patients is associated with changes in cardiac structural or functional parameters,suggesting that further screening for cardiovascular risk factors should be conducted in SLE patients with increased EFT and abnormal cardiac structure or functional parameters.
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