The investigation of false positive reactions about hepatitis C virus antibody detection in maintenance hemodialysis outpatients
Objective:To investigate the incidence and cause of false positive reaction about hepatitis C virus antibody detection in maintenance hemodialysis outpatients,in order to correctly deal with the antibody test reports and the doctor-patient communication problems.Methods:The hepatitis C virus antibody and RNA in 279 maintenance hemodialysis outpatients of General Hospital of Southern Theater Command of PLA were analyzed by cluster sampling,cross-sectional investigation and retrospective study from December 2019 to December 2022.Results:It was found that 81 patients were false positive for hepatitis C virus antibody,which accounted to 29.03%;S/CO values between 1.0 and 5.0 was 98.77%,and between 5.0 and 10.0 was 1.23%.All cases were reviewed by HCV-RNA three times,and were negative.Different detection methods and reporting procedures were chosen at the department of laboratory and the department of blood transfusion medicine,and the results were significantly different(P<0.01).Conclusion:The S/CO values of false positive reactions about hepatitis C virus antibody detection are mostly in the gray zone range and are related to the detection strategy and reporting procedure.
hemodialysisoutpatientshepatitis C virus antibodiesfalse positive reactions
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万方数据
