Establishment of reference intervals for thyroid function indicators in early pregnant women at different ages in Zigong
Objective:To establish the reference intervals for thyroid hormone measurements in healthy early pregnant women at different ages in Zigong,Sichuan Province,by using the indirect method,to provide evidence for clinical diagnosis and treatment.Methods:Data from healthy early pregnant women who had medical records in the Department of Obstetrics and Gynecology of the First People's Hospital of Zigong from January 2019 to December 2021,1 518 cases in total,were selected.The data were categorized into three groups according to the ages of pregnant women:group A(<26 years old),group B(26～34 years old),and group C(>34 years old),and the range from 2.5%to 97.5%was used as the reference interval.Conduct statistical analysis of the five thyroid hormones,including thyroid stimulating hormone(TSH),total triiodothyronine(TT3),total thyroxine(TT4),serum free triiodothyronine(FT3),and serum free thyroxine(FT4),in the data of three age groups.Results:There is no statistical difference among the three indicators of TSH,FT3 and FT4 in early pregnancy women of different ages,and the reference intervals for the three age groups were TSH(0.12～3.81 mIU/L),FT3(2.20～5.03 pmol/L)and FT4(4.79～16.13 pmol/L).There are statistical differences in TT3 and TT4 levels at different ages.The reference intervals of TT3 and TT4 in early pregnancy women under the age of 26 were 1.04～2.78 nmol/L and 91.80～204.88 nmol/L,while those in early pregnancy women over the age of 26 were 1.04～2.55 nmol/L and 82.70～190.00 nmol/L.The differences between group A,B,C and the non-pregnant group were statistically significant(P<0.05).Conclusion:The reference intervals for five thyroid hormone indicators in early pregnant women at different ages in Zigong,Sichuan Province have been established,providing a reference for clinical disease diagnosis,treatment,and prognosis judgment.
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