Investigation and evidence-based medicine evaluation of over-indications of thalidomide in outpatients
Objective:To explore the rationality of thalidomide(TLD)in outpatient use by evidence-based medicine evaluation method.Methods:A retrospective method was used to select 360 prescriptions containing TLD issued in outpatient clinics of the Sixth Affiliated Hospital of Sun Yat-Sen University in 2022.The off-label use was statistically analyzed,evaluated in evidence-based medicine evaluation path.The causes of off-label use were also analyzed.Results:The clinical use of TLD was off-label.The main indications were Crohn's disease,systemic lupus erythematosus and Behçet's syndrome.Evidence-based medical evidence evaluation is acceptable for use or could be used when other drugs were in valid or ineffective.The main reason for off-label drug use is that doctors believe that off-label drug use of TLD conforms to guidelines.Conclusion:The off-label use of TLD in outpatient clinics is supported by evidence-based medical evidence,but the off-label use of TLD should be strictly recorded in accordance with the record process.
NETL
NSTL
万方数据
