门诊患者超说明书使用沙利度胺的调查与循证医学评价
Investigation and evidence-based medicine evaluation of over-indications of thalidomide in outpatients
薛静1
作者信息
- 1. 中山大学附属第六医院 药学部,广东 广州 510655;广州市黄埔区中六生物医学创新研究院,广东 广州 510005
- 折叠
摘要
目的:采用循证医学评价方法,探讨沙利度胺(TLD)在门诊用药的合理性.方法:抽取2022 年中山大学附属第六医院门诊开具的包含TLD的处方360 张,对超说明书使用情况进行统计,采用循证医学评价路径进行评价,并对超说明书用药的原因进行分析.结果:门诊使用TLD均为超适应证用药,主要适应证为克罗恩病、系统性红斑狼疮和贝赫切特综合征.循证医学证据评价为可以使用或者可以在其他药物无效或效果不佳的情况下使用.超说明书用药的最主要原因是医生认为超说明书用药行为有指南等支持.结论:TLD在门诊的超说明书用药有循证医学证据支持,但仍应严格按照超说明用药备案流程进行备案.
Abstract
Objective:To explore the rationality of thalidomide(TLD)in outpatient use by evidence-based medicine evaluation method.Methods:A retrospective method was used to select 360 prescriptions containing TLD issued in outpatient clinics of the Sixth Affiliated Hospital of Sun Yat-Sen University in 2022.The off-label use was statistically analyzed,evaluated in evidence-based medicine evaluation path.The causes of off-label use were also analyzed.Results:The clinical use of TLD was off-label.The main indications were Crohn's disease,systemic lupus erythematosus and Behçet's syndrome.Evidence-based medical evidence evaluation is acceptable for use or could be used when other drugs were in valid or ineffective.The main reason for off-label drug use is that doctors believe that off-label drug use of TLD conforms to guidelines.Conclusion:The off-label use of TLD in outpatient clinics is supported by evidence-based medical evidence,but the off-label use of TLD should be strictly recorded in accordance with the record process.
关键词
沙利度胺/超说明书/循证医学/门诊患者Key words
thalidomide/off-label use/evidence-based medicine/outpatients引用本文复制引用
基金项目
广东省药学会肿瘤领域超说明书用药评价研究基金(2023)(2023ZLCS06)
广东省临床用药研究基金(2023)(2023JZ02)
出版年
2024
NETL
NSTL
万方数据