Objective:To study the prevalence of methicillin resistant Staphylococcus aureus(MRSA)infection in patients with osteomyelitis by meta-analysis.Methods:PubMed,Web of Science,CNKI,VIP,Wanfang,and CBM were searched for Prevalence of MRSA infection in patients with osteomyelitis from inception to August 2023.The data were independently screened and extracted by 2 investigators according to the inclusion and exclusion criteria and the quality of literature was evaluated using the NOS.Data were combined using prevalence as an outcome indicator,and meta-analysis was conducted using R(4.3.1)software with subgroup analysis based on types of osteomyelitis,age and research region.Results:A total of 26 papers containing 20 860 patients with osteomyelitis were included.Meta-analysis showed that the combined prevalence of MRSA infection in patients with osteomyelitis was 0.240(95%CI:0.183～0.297).Subgroup analyses showed a higher prevalence of MRSA infection in patients with VO,aged 18～60 years,and in patients with osteomyelitis in North America.Conclusion:The prevalence of MRSA infection is high in patients with osteomyelitis,and effective prevention and control measures are needed to reduce the transmission of MRSA.
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