Research progress of effects and mechanism of polycyclic aromatic hydrocarbons on cardiovascular diseases
Cardiovascular diseases(CVDs)are the most common non-communicable diseases in the world,with high morbidity,disability and mortality rates,and are a serious threat to human health.Studies have shown that CVDs are the leading cause of death in the world.Environmental pollution is an important risk factor for CVDs.Polycyclic aromatic hydrocarbons(PAHs)are common semi-volatile organic pollutants in the atmosphere.They can cause a variety of CVDs including hypertension,arrhythmias,atherosclerosis(AS)and congenital heart disease(CHD).This study systematically reviewed the relationship between PAHs and CVDs as well as the effects of PAHs exposure on CVDs,summarized the in vivo and in vitro experimental and epidemiological studies related to PAHs and CVDs,and elucidated the mechanisms of cardiovascular system damage(oxidative stress,inflammatory reaction,vascular homeostasis imbalance,cell electrophysiological abnormality,gene toxicity,etc.)induced by PAHs exposure.It provides important scientific basis and research direction for clarifying the harm of PAHs to CVDs,reducing the disease burden of CVDs and studying the pathogenesis of CVDs in the future.
万方数据
维普
