Progress of the mitochondrial fusion protein Mfn2 in Alzheimer's disease
Mitofusion2(Mfn2),a key factor regulating mitochondrial fusion,maintains dynamic changes in mitochondrial number,structure and biological functions by modulating the fusion and fission processes of mitochondria.The homeostasis of mitochondrial dynamics is the premise of regulating organelle function.Mitochondrial dysfunction is one of the characteristics of neurodegenerative diseases,including Alzheimer's disease(AD).In the brains of AD patients,β-amyloid(Aβ)aggregation and hyperphosphorylation of Tau proteins are accompanied by a significant decrease in the expression level of Mfn2,suggesting Mfn2 may play an important role in the pathogenesis of AD.This review focuses on the role of Mfn2 in mitochondrial dynamics of AD.Understanding the correlation between Mfn2 and the pathogenesis of AD will provide important information for the development of the treatment of mitochondrial dysfunction-related diseases.
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