Factors influencing intestinal microbiota across different life stages
As the largest and most complex microbial ecosystem within the human body,the intestinal microbiota forms a mutually beneficial symbiotic relationship with the host.The composition and function of the intestinal microbiota undergo changes throughout the entire life cycle while maintaining relative stability.With advancements in intestinal microbiota research technologies,recent studies have increasingly focused on the impact of genetic,nutritional,and environmental factors on the intestinal microbiota,with particular attention to the dynamic changes at different stages of life.The intestinal microbiota undergoes continuous development,maturation,and aging,exhibiting age-specific characters.Fetal microbiota begins to colonize in utero,and the mode of delivery and feeding practices lay the foundation for early colonization of the intestinal microbiota.The weaning process facilitates the gradual maturation of the intestinal microbiota.During adolescence and menopause,the substantial fluctuations in sex hormone levels interact with the intestinal microbiota.In the aging phase,changes in the intestinal microbiota are closely associated with immune aging and chronic low-grade inflammation.Antibiotics exert significant disruptive effects on the intestinal microbiota throughout the life cycle,especially with more pronounced effects in early life stage.This review analyzed the key factors influencing the normal initiation,maturation,and aging of the intestinal microbiota,aiming to explore the interrelationships between these factors and host physiological functions,providing a foundation for a deeper understanding of the dynamic changes in the intestinal microbial ecosystem.
万方数据
维普
