Correlation of peripheral blood cell ratio with rheumatoid arthritis disease activity and efficacy of infliximab
Objective:To explore the value of the peripheral blood parameters including neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR)and lymphocyte-monocyte ratio(LMR)in evaluating RA disease activity and drug efficacy.Methods:A retrospective study was conducted on 99 patients with active RA and 100 healthy subjects as the control group from December 2019 to December 2021.The differences of NLR,PLR and LMR between active RA groups and healthy control group,as well as the correlation between NLR,PLR,LMR and RA disease activity were analyzed.In 53 active RA patients who had received infliximab treatment for 14 weeks,the changes of NLR,PLR and LMR and their correlation with the efficacy of infliximab were analyzed in clinical responder group and clinical unresponder group.Results:①The NLR and PLR of the active RA group were higher than those of the healthy control group,while the LMR was lower than that of the healthy control group(P<0.05).②The NLR and PLR of low disease activity group were lower than those of medium/high disease activity group,while LMR was higher than that of medium/high disease activity group(P<0.05).③The NLR and PLR were positively correlated with DAS28-ESR,ESR and CRP in active RA patients.However,LMR was negatively correlated with DAS28-ESR,ESR and CRP(P<0.05).④ ESR,CRP,DAS28-ESR,NLR and PLR decreased and LMR increased significantly compared to baseline in RA patients treated with infliximab for 14 weeks(P<0.05).⑤ After treatment with infliximab,the clinical responder group had lower NLR and PLR than the clinical non-responder group,while the clinical responder group had higher LMR than the clinical non-responder group(P<0.01).Conclusion:Peripheral blood NLR,PLR and LMR in active RA can help evaluate disease activity and efficacy of infliximab.
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维普
